Set some time between the 33rd and 40th century, it shows the Great Human Empire, now ruled by 'Imperial King' Tiberius, having hunted down (almost) all remaining cybrids and expanded beyond the boundaries of the Solar system through the so-called Interstellar Transfer Conduit.

The chronologically first game in the Tribes series is Tribes: Vengeance which was released in 2004. Pursuing his goal of fortifying the Earth against the inevitable cybrid retaliation, Petresun ruthlessly exploits Martian and Venusian colonies, spawning massive resistance movements among the colonists by 2802. To counter this threat, Petresun (having technically achieved immortality through his studies) proclaims himself the Emperor of Mankind in 2652 and succeeds in unifying and rebuilding the Terran civilization. Prometheus, however, survives the assault, fleeing into deep space. In Starsiege, the Terran resistance manages to drive Prometheus' forces out of Earth and onto the Moon where they are believed to be eliminated by General Ambrose Gierling and his squad's suicide attack. By 2602, Prometheus grows wary of humans and rallies all cybrids against humanity.

Based on its design, thousands of cybrids are mass-produced as slaves. The Tribes series begins in 2471, when scientist Solomon Petresun invents the first cybrid, a bio-cybernetic hybrid artificial intelligence named Prometheus. Tribes is a spin-off series from the mecha simulation series Metaltech. The series includes Starsiege: Tribes, Tribes 2, Tribes: Aerial Assault, Tribes: Vengeance, and Tribes: Ascend. The game plot is set in the far future (2471 – 3940). Tribes is a series of five science fiction first-person shooter video games released between 19.

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